According to the Egyptian Ministry of Health, a bus crashed into a canal in the Nile Delta region on Saturday, killing at least 21 people.
Three children were among the dead, said Dr. Sherif Makin, an official with the Department of Health.
The ministry said in a statement that the accident happened in Dakahlia province, about 100 kilometers northeast of the capital Cairo. The other injured passengers were taken to a local hospital.
The head of the provincial police investigation, Brig Gen Muhammad Abd al-Hadi, said the driver may have lost control of the steering wheel.
Fatal road accidents claim thousands of lives each year in Egypt, which has a poor road safety record.
Accidents and collisions mainly occur due to speeding, bad roads or poor enforcement of traffic rules.
In July, a passenger bus collided with a truck parked on a highway in southern Minya province, killing 23 and injuring 30.